American and German researchers led by Lothar Schermelleh of Department of Biology of the University Ludwig Maximilians of Munich devised a microscope for generating three-dimensional movies of live cells. The microscope, will let scientists watch how cells behave in real time at a greater level of detail.
This study, was published in an article today in Science, "opens interesting new perspectives for molecular cell biology."
A new microscope has a 100 nanometer resolution, up from the 200 to 300 nanometer focus of conventional microscopes: by mixing several beams of light to create a lighting pattern that varies both horizontally and vertically, can produce images for high-resolution, multi-colored, three-dimensional and reveal more details than ever before seen with conventional microscopes.
Lothar Schermelleh and colleagues developed this new imaging technique called three-dimensional structured illumination (3D-SIM), of the cells’, and were even able to label different components of the cell with different colors a feat never before accomplished.
This new development allows for interesting new perspectives on molecular cell biology, yet does not require any unconventional equipment and is no more difficult to use than a normal, commercial microscope.